An Application of Mechanistic Toxicology

Using the same global gene expression data set used to predict a compound's toxicity (ToxScreen™ Reports or ToxShield™ Suite), Gene Logic's molecular toxicologists are often able to prepare a detailed analysis of the underpinning biology that drives predicted or observed toxicity. Whole genome profiling analyses can provide unique insight, even with the most subtle toxicities.

The analysis for a Mechanism of Toxicity (MOT) Report builds a comprehensive picture of the molecular events pertinent to the toxicity by taking the set of genes whose expression is perturbed by compound treatment and viewing it in the context of a wide body of knowledge. This body of knowledge includes Gene Logic's molecular toxicologists' expertise, literature findings, known pathway connections, novel pathway and co-regulated relationships, and compound comparisons to benchmark biological changes between the test article and ToxExpress® System reference compounds (including time and dose responses).

We begin each project with an in-depth scientific discussion with you to determine the scope of the project. A typical experiment involves an in-life component, a gene expression data generation component, and gene expression data analysis. You can start with a test article, test article-treated tissues or RNA, or Affymetrix gene expression data. We can work with you to perform needed in-life studies or generate your microarray data through additional custom services (see Preclinical Services and Microarray Data Generation & Analysis Services).

Detailed product information is available for your review at ToxExpress® Program Literature.