ToxExpress® System
The foundation of Gene Logic’s ToxExpress® Program is our ToxExpress® System. Developed in collaboration with major pharmaceutical companies, the ToxExpress® System is the largest database of its kind, comprised of over 14,000 individual vehicle and normal control and drug-treated animal tissue samples. A consortium of our customers stringently evaluates compound selection, study protocols, and in-life data, resulting in a consistent, robust database that serves as a premier reference source for both gene expression and related in-life toxicology data.
The ToxExpress® System is designed to help extensively characterize compounds, to facilitate the drug development process and aid in decision-making. The ToxExpress® System supports end-user research efforts and extensive knowledge building in four major areas:
- Investigative Toxicology
- Predictive Toxicology
- Mechanistic Toxicology
- Safety Biomarker Discovery
Overview of the ToxExpress® System capabilities and benefits:
| Capability of ToxExpress® System | Benefit to Customer |
|---|---|
| Ability to measure expression changes by any number of statistical methods | Provides reproducibility and robustness of expression changes |
| Ability to view and analyze expression data and pathways, clinical pathology data and histopathology simultaneously | Allows data mapping across disparate sources of information in an easy-to-understand interface |
| Ability to test for species specificity of genes/pathways | Provides insight into possible risk and points to way to migrate risk |
| Ability to identify markers that could be used in downstream or upstream assays to screen backups or other members of a compound series | Expedites evaluation of other compounds and helps with drug rescue strategies |
| Ability to understand the underlying biology that is affecting or causing an adverse event, often from a single experiment | Accelerates research and identifies secondary screens far faster than conventional methods |
| Ability to examine dose and time response within a study or cohort or across any number of compounds | Establishes relationships and identifies potential pathways or genes that could be used as screens for other related compounds |
You can access the ToxExpress® System through flexible subscription terms: choose a subscription to the entire ToxExpress® System or select ToxSuite™ Datasets relevant to specific organ and/or tissue types.
+1-301-987-1700
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